Dectin-2 family

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August undefined, 2024

Dectin-2 is a member of C-type lectin receptor family, which is a group of pattern recognition receptors involved in antifungal immunity, homeostasis and induction of immune response to pathogens. Its carbohydrate recognition domain is capable of binding α-mannans in fungal cell walls. Upon ligand … See more Dectin-2 or C-type lectin domain containing 6A is a protein that in humans is encoded by the CLEC6A gene. Dectin-2 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The … See more Dectin-2 is a glycosylated type II transmembrane protein which is encoded by six exons. It consists of a single C-type lectin (carbohydrate recognition domain, CRD) domain in its … See more Anti-fungal immunity Dectin-2 signaling is an essential component of host defense against fungal infections. It has been observed that dectin-2 preferentially induces the Th17 response, which is essential for effective host protection and … See more WebFeb 13, 2024 · Dectin-2, a member of the C-type lectin receptor family, participates in a variety of immune responses. What New Information Does This Article Contribute? …

C-TYPE LECTIN DOMAIN FAMILY 6, MEMBER A; CLEC6A

WebAug 7, 2009 · The Dectin-2 gene family includes BDCA-2, DCAR, DCIR, Dectin-2, Clecsf8 and Mincle, and form a cluster (red square) in the telomeric region of the NKC, close to the Dectin-1 cluster (blue square), on mouse chromosome 6 and human chromosome 12. 2. The Dectin-2 family of C-type lectins: an overview WebCLECSF8 is a poorly characterized member of the “Dectin-2 cluster” of C-type lectin receptors and was originally thought to be expressed exclusively by macrophages. We show here that CLECSF8 is primarily expressed by peripheral blood neutrophils and monocytes and weakly by several subsets of peripheral blood dendritic cells. However, expression … bird wearing motorcycle helmet

National Center for Biotechnology Information

WebDectin-2 family Pathway - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National Center for … WebDectin-2. Dectin-2 (a type II transmembrane receptor) is a receptor for high mannose structures, and is found on DCs, monocytes, macrophages, and neutrophils. Dectin-2 … WebAs a member of this receptor family, dectin-1 recognizes β-glucans and carbohydrates found in fungal cell walls, some bacteria and plants, but may also recognize other … bird wearing glasses

Dectin-2 Gene Sequence, Family, Fuction and Expression …

C-Type Lectin Receptors Review InvivoGen

WebDec 6, 2016 · Here, we show that Dectin-2, a C-type lectin receptor (CLR) family of innate receptors, is critical for the suppression of liver metastasis of cancer cells. We provide … WebNational Center for Biotechnology Information. 8600 Rockville Pike, Bethesda, MD, 20894 USA. Contact. Policies. FOIA. HHS Vulnerability Disclosure. National Library of Medicine. National Institutes of Health. Department of Health and Human Services. bird wearing a hatWeband endosomal TLRs, but also dectin-1 and cytosolic NOD-like receptor (NLR) family members. Stimulation of these PRRs (TLR-2, TLR-4, and dectin-1) during infection with A. fumigatus subsequently leads to activation of transcription factors such as NF-kB, whose translocation into the nucleus stimulates the dancers pointe howell nj

"WebJul 15, 2024 · In this study, we show that TNF is sufficient to upregulate MINCLE, MCL, and DECTIN-2 in macrophages. TNF signaling through TNFR1 p55 was required for upregulation of these CLR and for cytokine secretion in macrophages stimulated with the MINCLE ligand trehalose-6,6-dibehenate or infected with Mycobacterium bovis bacillus … " - Dectin-2 family

Dectin-2 family

Dectin-1 and Dectin-2 in innate immunity against fungi

WebDectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. WebDendritic cell-associated C-type lectin-1 (Dectin-1), also known as β-glucan receptor is an emerging pattern recognition receptor (PRR) which belongs to the family of C-type lectin receptor (CLR). This CLR identifies ligands independently of Ca2+and is majorly involved in coupling of innate with adaptive immunity.

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WebOct 1, 2009 · The Dectin-2 family are multifunctional receptors, and have been shown to be important in both homeostasis and immunity. Many can act as PRRs and they recognize a range of pathogens, including fungi and viruses and probably others. Many also recognize endogenous ligands, highlighting the importance of this family in homeostasis. ... WebMar 30, 2024 · Dectin-1 mediated Syk activation is required for TLR9 trafficking to β-1,3 glucan, A. fumigatus, and C. albicans containing phagosomes. In addition, Dectin-1 regulates TLR9 dependent gene expression.

WebApr 12, 2013 · The Dectin-2 family of C-type lectin receptors are encoded at the telomeric end of the NK gene cluster on human chromosome 12 (A) and mouse chromosome 6 … WebApr 12, 2013 · The Dectin-2 family of C-type lectin receptors are encoded at the telomeric end of the NK gene cluster on human chromosome 12 (A) and mouse chromosome 6 (B). (C) Schematic representation of signal transduction pathways induced by the various Dectin-2 family CTLRs. BLNK, B-cell linker protein; BTK, Bruton’s tyrosine kinase; TM, …

WebMay 1, 2013 · Of relevance here is the dendritic cell-associated C-type lectin-2 (Dectin-2) family of CTLRs, which includes blood dendritic cell antigen 2 (BDCA-2), dendritic cell … Web2024 CiteAb Awards - View the winners now! ... Search

WebDectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are …

WebDectin-2 binds high mannose-type carbohydrates and was shown to be the functional receptor for α-mannans. Moreover, Dectin-2 has been implicated in anti-bacterial immunity and allergy [7]. Like Dectin-1, Dectin-2 belongs … dancers on laugh inWebFeb 1, 2024 · Dectin-2 has been implicated in the defense against numerous pathogens, including C. albicans, C. neoformans, A. fumigatus, Saccharomyces cerevisiae, Paracoccidioides brasiliensis, Histoplasma capsulatum, Microsporum audouinii, Trichophyton rubrum, Mycobacterium tuberculosis, and Schistosoma mansoni ( 75, 78, 80 ). bird wearing a hoodieWebMar 18, 2015 · Among in vitro-generated dendritic cells (DCs), expression of dectin-2 was strongest in immature Langerhans cell (LC)-type DCs. By searching databases for … dancers on the jackie gleason showWebJun 23, 2024 · Dectin-2 cDNA / Gene Function The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular … dancers on the carol burnett showWebSep 3, 2014 · Zhu et al. (2013) expressed chimeric receptors with the extracellular domain of human dectin-3, BDCA2 (CLEC4C), MINCLE, or DCIR, which all belong to the dectin-2 gene cluster, fused to the transmembrane and intracellular domain of human dectin-2 (CLEC6A; 613579) in a mouse macrophage cell line. dancers named gregoryWebMar 14, 2024 · The C-type lectin receptors (CLR) MINCLE, MCL, and DECTIN-2 are expressed on myeloid cells and sense mycobacterial cell wall glycolipids. In this study, … bird webcamWebJun 15, 2011 · Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular … bird weathervanes