WebAug 1, 2004 · GATA-4 and -6 regulate expression of several cardiac-specific genes, and during murine embryonic development, GATA-4 is essential for proper cardiac … WebGATA4 is an essential transcriptional regulator required for gonadal development, differentiation, and function. In the developing testis, proposed GATA4-regulated genes include steroidogenic factor 1 (Nr5a1), SRY-related HMG box 9 (Sox9), and anti-Müllerian hormone (Amh). ... Did you know that heart disease and stroke is the #1 cause of ...

Co-occupancy by multiple cardiac transcription factors ... - PNAS

WebMar 3, 2010 · Major contribution of gata4 + cardiomyocytes to heart regeneration. a, gata4:ERCreER; β-act2:RSG animals injected once daily with vehicle (left) or 4-HT at 5–7 dpa, before collection at 9 (center; n = 5) or 14 dpa (right; n = 6). EGFP fluorescence (arrows) is observed at injury borders by 9 dpa and within the injury site by 14 dpa. WebMar 25, 2010 · While searching for molecular markers informative for regeneration, we identified a unique expression pattern driven by upstream regulatory sequences of gata4, a transcription factor gene... low heat on electric stove

GATA-4 Is an Angiogenic Survival Factor of the Infarcted Heart

WebJun 30, 2024 · GATA4 gene is expressed in all types of cardiac cells. GATA4 regulates many cardiac genes in the process of cardiac morphogenesis [ 10, 11 ]. During the heart development, GATA4 plays an essential role for proepicardium generation, heart tube formation, separation and outflow tract development. WebJan 4, 2011 · Abstract. We report that the dominant human missense mutations G303E and G296S in GATA4, a cardiac-specific transcription factor gene, cause atrioventricular septal defects and valve abnormalities by disrupting a signaling cascade involved in endocardial cushion development. These GATA4 missense mutations, but not a mutation causing … GATA4 is expressed in both embryo and adult cardiomyocytes where it functions as a transcriptional regulator for many cardiac genes, and also regulates hypertrophic growth of the heart. GATA4 promotes cardiac morphogenesis, cardiomyocytes survival, and maintains cardiac function in the … See more Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene. See more This gene encodes a member of the GATA family of zinc finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and … See more GATA4 has been shown to interact with NKX2-5, TBX5, Serum response factor HAND2, and HDAC2. GATA4 has also … See more • GATA transcription factor See more GATA4 expression during cardiac development has been shown to be essential to proper atrioventricular (AV) formation and function. Endocardial cells undergo epithelial … See more Mutations in this gene have been associated to cases of congenital diaphragmatic hernia. Atrial septal defects, tetralogy of Fallot, and ventricular septal defects associated with GATA4 mutation were also seen in South Indian patients. See more • Evans T, Reitman M, Felsenfeld G (1988). "An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes" See more jarrod woodgate and sam royce