WebDec 1, 2024 · Transgenic CD47 overexpression is an encouraging approach to ameliorating xenograft rejection and alloresponses to pluripotent stem cells, and the efficacy correlates with the level of CD47 expression. However, CD47, upon ligation, also transmits signals leading to cell dysfunction or death, ... WebMar 17, 2024 · In haematological and solid malignancies, overexpression of CD47 on tumour cells is associated with poor survival. 12-14 Targeting the CD47–SIRPa axis checkpoint is currently investigated in clinical trials across several haematological malignancies, including cHL, 15, 16 with encouraging results in non-Hodgkin lymphoma. 17
Expression of CD47 in Glioblastoma Multiforme and Implications …
WebMar 7, 2024 · Our data establish that an active mre-11 is required for the induction of CD47 overexpression upon DNA damage, as CD47 upregulation in response to γ-irradiation was … WebJun 23, 2024 · In support of this, overexpression or depletion of CD47 in intestinal epithelial cell lines suppressed or enhanced the expression of cellular Oct4, Klf4, Sox2 and c-Myc, … chick-fil-a grilled nuggets calories 12 count
Human hypoimmune primary pancreatic islets avoid rejection and ...
WebGlioblastoma multiforme (GBM) is a fast growing, malignant primary brain tumor that occurs most frequently in adults and accounts for approximately 15% of all brain tumors. With a median survival time WebJul 17, 2024 · In cancers, recognition of CD47 overexpression on the surface of cancer cells by its receptor, SIRPα on the phagocytic cells, inhibits phagocytosis of cancer cells. Thus, blocking of CD47‐SIRPα signaling axis might be as a promising therapeutic target, which promotes phagocytosis of cancer cells, antigen‐presenting cell function as well as … WebCD47 is a potent ‘do not eat me’ signal that enables cancer cells to evade detection by the innate immune system, thereby avoiding destruction by first responder cells, such as … gordon ramsay\u0027s family